Phenibut is derived from the inhibitory neurotransmitter known as GABA and it is known to act as a GABA mimetic at GABA-B receptors and to a lesser extent at GABA-A receptors. While neurotransmitters like dopamine and acetylcholine are excitatory and cause neurons to become stimulated, GABA has the opposite effect. Its primary method of action is to inhibit the stimulation of neurons which allows the body and brain to calm down. Phenibut is known to selectively target neurons that have become ‘excited’ and are too active, continuously firing. Excessively active neurons are one of the key signs of anxiety disorder. Once targeted, Phenibut regulates the firing of these neurons, which leads to a feeling of tranquility and relaxation.
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